The contents of Clinical Pharmacy and Pharmacy Management have been integral aspects of Pharmacy training at the undergraduate and postgraduate levels, but it was not until 1999 that these contents were isolated and drafted into an independent department at the Faculty of Pharmaceutical Sciences of the University of Nigeria Nsukka. The creation of the department became inevitable as the primary focus of Pharmacy training worldwide shifted to the production of clinically-oriented Pharmacists to cope with the new and emerging roles of Pharmacists in all sectors: hospital, community, administration, etc. The department had four (4) as the inaugural academic members of staff. At present, there are thirteen lecturers who are supported by administrative and technical staff.

Since inception, the department has been led by a number of capable members of staff. The pioneer (acting) head of the department was Prof. (Mrs.) Chinwe V. Ukwe who served from 1999 to 2007 and 2009 to 2012. She was succeeded by Prof. J. M. Okonta (2007 to 2009 and 2012 to 2015), then Dr. M. O. Adibe (2015 to 2016). The present head of department is Dr. C. M. Ubaka (2017 to date).